Endocrine Abstracts

A third of UK residents develop cancer, but the risk of being diagnosed under age 50 years is under 4%. The four most common cancers account for 54% of all cases: breast (16%), lung (13%), colorectal (13%) and prostate (12%). Five-year age standardised survival has increased substantially in recent decades for breast, prostate and colorectal cancer resulting in latest figures of 77, 65 and 48%, respectively. Cancer is increasingly becoming a curable or chronic disease. At the ...

Objective: to investigate whether periconceptual undernutrition in sheep alters the timing and activation of the fetal HPA axis and thus pregnancy duration. Preterm birth is a major health problem, but its causes are poorly understood.Methods: Twentyeight nulliparous ewes were randomly assigned to an ad libitum (N, n=8) or restricted diet (maternal body weight reduced by 15-20%; UN, N=10) from 61 d before to 30 d after mating. Therea...